Table 2

Modifications to the MDACC concurrent biochemotherapy regimen

Prophylactic antibiotics
Replace central lines each cycle (days 5–6)
Reduce vinblastine to 4.8 mg/m2 per cycle.
G-CSF (days 7–16)
Aggressive antiemetics; delayed discharge and/or outpatient i.v. hydration if needed
Strict, conservative, and explicit dose modification criteria for:
Renal insufficiency
Hematological toxicity
CNS toxicity
Maximum of four cycles