Table 4

Summary of pharmacokinetic parameters of plasma DMDC

Dose of DMDCDayCmax (μg/ml)tmax (h)t1/2 (h)
12 mg/m2/day (n = 7)1Mean0.11291.44051.7496a
SD0.02930.77980.4126
CVb (%)25.9454.1423.58
14Mean0.07431.32141.9441c
SD0.04310.46750.4309
CV (%)58.0935.3822.16
18 mg/m2/day (n = 7)1Mean0.14571.21432.3512a
SD0.05830.70030.2997
CV (%)39.9957.6712.75
14Mean0.12431.61902.4822c
SD0.04430.50430.4342
CV (%)35.6431.1517.49
  • a P < 0.01.

  • b CV, coefficient of variation.

  • c P = 0.047.