Table 1

Immunoistochemical analysis of GEO tumors following treatment with Taxol and/or oral MBOs

Analysis was performed at the end of the second cycle of treatment (day 27) on three different tumor specimens randomly selected in each group. Numbers represent the percentage of positive cell staining for each antigen (see “Materials and Methods”). Numbers in parentheses represent the SD (%) in the measurement of each biological parameter. The intensity of staining is represented by a score from + to +++.

Ki67RIαARTGFαp27Vessels
Control40% (±5)70% (±4)85% (±7)50% (±4)10% (±2)15 (±2)
+++++++++++++
Taxol20% (±2)60% (±5)70% (±5)50% (±3)10% (±2)5 (±2)
++++++++++
AS RIα MBO28% (±5)35% (±3)50% (±3)20% (±3)15% (±3)3 (±1)
++++++++
Scramble MBO30% (±4)60% (±5)85% (±8)50% (±3)8% (±2)14 (±2)
+++++++++++++
AS RIα MBO+ Taxol6% (±1)15% (±3)25% (±3)30% (±3)25% (±4)0
++++++
Scramble MBO+ Taxol28% (±3)60% (±5)70% (±5)50% (±5)8% (±2)7 (±2)
+++++++++