Table 1

LOH frequencies in invasive lung cancers (n = 68) and accompanying bronchial epithelia (n = 119)

Chromosomal regionsInvasive tumorsBronchial epithelial samples
ADC n = 21SQC n = 25SCLC n = 22ADC n = 47SQC n = 41SCLC n = 31
3p122/14 (14%)11/12 (92%)7/9 (78%)0/32a1/30 (3%)2/10 (20%)
3p14 FHIT5/16 (31%)19/21 (91%)13/16 (81%)0/431/40 (3%)3/27 (11%)
3p217/20 (35%)22/24 (92%)16/19 (84%)0/47a15/41 (37%)b8/25 (32%)
3p22–244/18 (22%)18/23 (78%)17/22 (77%)1/47 (2%)a3/41 (7%)6/31 (19%)
Any 3p10/21 (48%)23/25 (92%)19/22 (86%)1/47 (2%)a14/41 (34%)b14/31 (45%)
4p0/102/6 (33%)6/11 (55%)0/232/21 (10%)4/23 (18%)
4q25–320/64/8 (50%)6/9 (67%)0/27a2/31 (7%)7/31 (23%)
5q21–220/143/11 (27%)11/16 (69%)0/36a0/307/22 (32%)c
6q16–214/16 (25%)4/9 (44%)7/13 (54%)0/360/352/13 (15%)
8p21–236/19 (32%)22/24 (92%)6/21 (29%)0/39a3/41 (7%)8/30 (27%) c
9p2110/16 (63%)9/13 (69%)10/19 (53%)2/43 (5%)a4/38 (11%)10/31 (32%)c
13q14 RB5/15 (33%)4/14 (29%)10/15 (67%)1/31 (3%)0/252/16 (13%)
17p13 TP538/18 (44%)18/22 (82%)18/20 (90%)1/38 (3%)a0/3112/19 (63%)c
Any region19/21 (90%)25/25 (100%)22/22 (100%)5/47 (10%)a22/41 (54%)b28/31 (90%)c
  • a Significant differences between bronchial epithelium accompanying ADC and SCLC were detected at 3p12 (P = 0.041), 3p21 (P < 0.001), 3p22–24 (P = 0.014), any 3p (P < 0.001), 4p (P = 0.006), 4q25–32 (P = 0.013), 5q21 (P < 0.001), 8p21–23 (P = 0.001), 9p21 (P = 0.002), 17p13 (P < 0.001), and any region (P < 0.001).

  • b Significant differences between bronchial epithelium accompanying ADC and SQC were detected at 3p21 (P < 0.001), any 3p (P < 0.001), and any chromosomal region (P < 0.001).

  • c Significant differences between bronchial epithelium accompanying SQC and SCLC were detected at 5q21 (P = 0.005), 8p21–23 (P = 0.029), 9p21 (P = 0.026), and 17p13 (P < 0.001), and any chromosomal regions (P < 0.001).