Table 2

Summary of the major differences in the genetic changes detected between lung cancer types

Genetic markerInvasive tumorBronchial epithelium
ADCSQCSCLCADCSQCSCLC
5q21–22 LOH027%69%0032%a
8p21–23 LOH32%92%29%07%27%a
9p21 LOH63%69%53%5%11%32%a
17p13-TP53 LOH44%82%80%3%063%a
Any chromosomal region LOH90%100%100%10%54%90%a
Mean FRL-subject indexb0.010.090.31a
Mean FRL-sample index0.390.710.850.010.080.27a
Epithelium FRL-sample index/tumor FRL-sample index0.030.110.32
MA index0.0190.0240.0780.0060.0060.063c
MA frequency24% 32% 50%13%10%68%a
  • a P < 0.001 (significant difference between bronchial samples obtained from SCLC and the other histological types of lung cancer.

  • b Mean FRL-sample index was calculated using only the epithelial samples from each subject.

  • c P < 0.001 (significant difference between bronchial samples obtained from SCLC and the other histological types of lung cancer.