Table 2

Effect of NU1085 and NU1025 on TP-induced growth inhibition in human tumor cell lines

Cell lineIC50a (nm)
TPTP + 10 μm NU1085TP + 50 μm NU1025TP + 200 μm NU1025
A549 (lung)>7552 (>1.4)b68 (>1.1)40 (>1.9)
7019 (3.7)32 (2.2)17 (4.1)
8331 (2.7)62 (1.3)51 (1.6)
CORL23 (lung)6164 (0.9)28 (2.2)41 (1.5)
6164 (0.9)28 (2.2)25 (2.4)
H522 (lung)>300122 (>2.4)81 (>3.7)58 (>5.2)
25191 (2.8)30 (8.4)46 (5.5)
SKOV3 (ovary)5029 (1.7)25 (2.0)24 (2.1)
2319 (1.2)16 (1.4)12 (1.9)
3826 (1.5)26 (1.5)24 (1.6)
A2780 (ovary)237.8 (2.9)8.5 (2.7)8.5 (2.7)
227.9 (2.8)8.7 (2.5)8.1 (2.7)
OAW-42 (ovary)2521 (1.2)20 (1.3)12 (2.7)
2719 (1.4)16 (1.7)16 (1.7)
HT29 (colon)6623 (2.8)45 (1.5)38 (1.7)
>7545 (>1.7)34 (>2.2)37 (>2.0)
7228 (2.6)28 (2.6)34 (2.1)
LoVo (colon)23550 (4.7)79 (3.0)52 (4.5)
29192 (3.2)90 (3.2)71 (4.1)
LS174T (colon)109 (1.2)8 (1.3)8 (1.3)
1010 (0.9)8 (1.3)9 (1.2)
MCF-7 (breast)>30095 (>3.2)168 (>1.8)98 (>3.1)
>300155 (>1.9)233 (>1.3)149 (>2.0)
T47D (breast)9229 (3.2)24 (3.8)34 (2.7)
271229 (1.2)211 (1.3)210 (1.3)
MDA-231 (breast)>300>300>300>300
>300>300136 (>2.2)>300
  • a Data were from individual experiments, using five replicates for all samples.

  • b Numbers in parentheses, PF50 values derived from the individual experiments. Where IC50s were not attained by the highest concentration of TP used (300 nm), PF50s were expressed as greater than the value calculated, assuming the IC50 for TP alone to be 300 nm.