Table 3

Comparison of the growth-inhibitory and cytotoxic effects of NU1025 and NU1085 as single agentsa

Cell lineNU1025 IC50m)NU1025 LC50m)NU1085 IC50m)NU1085 LC50m)
A549>1000>1000, >1000, >100083 ± 1874 ± 8
LoVo330 ± 139901, >1000, >100094 ± 1170 ± 24
OAW-42263 ± 119920 ± 6782 ± 880 ± 20
  • a Data are presented either as the mean of three or more independent experiments ± SD or as the results of individual experiments. IC50s were calculated as described in “Materials and Methods.” LC50s were determined directly from the survival curves, which were plotted point to point.