Table 3

Univariate and multivariate analysis of the dichotomized Mn-SOD parameters of carcinomas and normal mucosa in relation to the overall survival of patients with gastric cancera

Parameter dichotomizedSurvivors/total n/n (%)Median survival (mo)Cox hazard ratio (95% CIb, P)
UnivariateMultivariate
CA
Mn-SOD level
≤450c6/17 (35.3)36
>4509/64 (14.1)142.1 (1.1–4.1, 0.03)1.9 (0.9–3.9, 0.08)
NM
Mn-SOD level
≤335c2/30 (6.7)10
>33513/51 (25.5)220.6 (0.3–0.9, 0.02)0.6 (0.3–1.1, 0.08)
Mn-SOD ratio
CA:NM
≤2.0311/44 (25.0)27
>2.034/37 (10.8)131.7 (1.0–2.7, 0.04)1.9 (1.1–3.2, 0.03)
  • a Multivariate analysis was performed by adjusting each SOD parameter to the clinicopathological parameters gender and age of the patients, TNM stage, Laurén classification, WHO classification, localization, diameter, number of eosinophils of the tumors, and intestinal metaplasia of the normal mucosa.

  • b CI, confidence interval; CA, carcinoma; NM, normal mucosa.

  • c ng/mg of protein.