Table 3

Probabilities of reaching CR1 and OS in AML patients

No. of patientsCR1 (%)OS (5 yrs) (%)
Risk group
Good810086
Poor894517
Very poor7140
Age (yrs)
≤35414119
35–55505221
>55134615
Rh123 EBFa PSC833
Low (≤1.2)384522
Medium326935
High (≥2.3)34290
Rh123 accumulation
Low (≤95853b)32250
Medium336121
High (≥231216b)335833
CF EBF MK-571
Low (≤1.8)365026
Medium365023
High (≥2.6)324111
CF accumulation
Low (≤153745b)323413
Medium336126
High (≥230969b)334826
EBF of Rh123 and CF
Lowc575623
Medium335234
Highc1400
Rh123 and CF accumulation
Lowd1660
Medium715420
Highd117367
GSH (%)
Low (≤20)313513
Medium344425
High (≥42)295219
  • a EBF, efflux-blocking factor.

  • b Rh123 and CF accumulation, expressed as MESF units.

  • c Low, Rh123 EBF of PSC833 ≤ 3.25 and CF EBF of MK-571 ≤ 2.3; high, Rh123 EBF of PSC833 > 3.25 and CF EBF of MK-571 > 2.3; medium, all other values.

  • d Low, Rh123 accumulation ≤ 9,000 and CF accumulation ≤ 157,900 MESF units; high, Rh123 accumulation > 9,000 and CF accumulation > 350,000 MESF units, medium: all other values.