Table 1

Methylation patterns of the p15 and p16 genes in tumors, plasma/serum, and buffy coat samples from 25 HCC patients

Patient no.HBsAg/cirrhosisaTumor size (cm)Tumor methylation statusPlasma/serum methylation statusBuffy coat p15 methylation statusClinical evidence of recurrence/metastasis (days after surgery)
p15p16p15p16
1−/−2.8bYes (465)
2+/+4.5No
3+/+1.8No
4+/+4.0Yes (150)
5+/−5.6 n Yes (285)
6+/+11.0 n Yes (209)
7+/+6.0 n Yes (150)
8+/−5.1 n No
9+/+7.5 n Yes (139)
10+/+2.4No
11+/+2.4 n Yes (249)
12+/−4.5No
13+/+1.4No
14+/+6.5No
15−/−9.5Yes (164)
16+/+6.6No
17+/−8.5No
18+/+1.8 n No
19+/+8.0 n Yes (134)
20+/+4.8Yes (540)
21+/+4.0Yes (510)
22+/+8.0No
23−/+5.5Yes (270)
24+/+5.8 n Yes (30)
25+/−5.7 n No
  • a HBsAg, hepatitis B surface antigen.

  • b •, methylated; ○, unmethylated; n, not analyzed.