Table 1

Number (percentage) of melanocytic tumors expressing different levels of cyclin D1 and D3

Tumor typeNo. of tumors examinedCyclin D1aCyclin D3a
++++++++++++
Primary melanomas17265 (38)91 (53)13 (7)3 (2)7 (4)117 (68)35 (20)13 (8)
Superficial11036 (33)64 (58)8 (7)2 (2)6 (5)82 (75)20 (18)2 (2)
Nodular6229 (47)27 (43)5 (8)1 (2)1 (2)35 (56)15 (24)11 (18)
Metastatic melanomas7352 (71)18 (25)2 (3)1 (1)2 (3)32 (44)22 (30)16 (22)
Benign nevi1010 (100)0 (−)0 (−)0 (−)0 (−)10 (100)0 (−)0 (−)
  • a Expression of cyclins D1 and D3 was measured as described in “Materials and Methods.” −, none;+ , <5%; ++, 5–50%; and +++, >50%.