Table 2

Relationship between cyclin D1, cyclin D3, and depth of tumor growth of primary melanomas

Tumor typeImmunohistochemistryNo. of patientsbDepth of growthc (mm)P
MarkerExpression levela
SuperficialCyclin D1Low971.820.59
High101.51
Cyclin D3Low851.510.03
High222.89
NodularCyclin D1Low554.850.03
High62.51
Cyclin D3Low354.270.22
High265.09
  • a Expression level was scored as described in “Materials and Methods:” −/+, low expression;++ /+++, high expression.

  • b Tumor thickness was available for a total of 168 patients (107 superficial and 61 nodular melanomas).

  • c Measured as the mean thickness in each group.