Table 4

Relationship between expression of cyclin D1, cyclin D3, cyclin A, and Ki-67

Type of lesionNo. of tumors analyzedImmunohistochemistryExpression of cyclin D1aExpression of cyclin D3a
MarkerExpression levelLowHighPLowHighP
Superficial110Cyclin D1Low84160.0009
High46
110Cyclin ALow67330.026280.002
High372614
110Ki-67Low83170.00017711<0.000001
High37913
Nodular62Cyclin D1Low31250.19
High51
62Cyclin ALow14420.651150.31
High242521
62Ki-67Low25310.8018180.37
High331016
  • a Expression of cyclins D1 and D3 was measured as described in “Materials and Methods:” −/+, low expression; ++/+++, high expression.