Table 3

p53 mutations and p53 protein overexpression in ovarian carcinomas

Type of mutationmmunohistochemistryP
Negativen (%)Positiven (%)
Missense mutation4 (6)67 (94)
Nonsense mutation6 (86)1 (14)
Insertion/Deletion5 (38)8 (62)
Splice site mutation4 (50)4 (50)<0.001
Total p53 mutations19 (19)80 (81)
p53 wild-type49 (62)30 (38)<0.001