Table 4

Response to platinum-based chemotherapy in correlation to p53 alterations

Response to chemotherapyImmunostainingp53 sequenceType of mutation
Negativen (%)Positiven (%)Wild-typen (%)Mutationn (%)Wild-type/Nonmissensen (%)Missensen (%)
Sensitive21 (78)18 (39)22 (65)17 (44)29 (66)10 (34)
Resistant/Refractory6 (22)28 (61)12 (35)22 (56)15 (34)19 (66)
P 0.0010.0710.008
Total (100%)274634394429