Table 5

Multivariable proportional hazards Cox regression analysis for the identification of independent prognostic factors in overall survival of patients with ovarian carcinoma

Variables in the baseline modelaUnivariate analysisMultivariable analysis
Unadjusted relative risk(95% CI)PbAdjusted relative risk(95% CI)Pc
 FIGO<0.0010.002
  I + II1.001.00
  III + IV6.98(3.51 –13.87)3.59(1.49 –8.66)
 Residual disease<0.001<0.001
  None1.001.00
  Any4.77(3.00 –7.58)2.44(1.46 –4.09)
 Histological grade<0.0010.009
  Well-differentiated1.001.00
  Moderately3.99(1.67 –9.50)3.26(1.13 –9.43)
  Poorly5.95(2.58 –13.71)3.87(1.37 –10.88)
The p53 variables
 Immunostaining0.0560.73
  No1.001.00
  Yes1.45(0.98 –2.14)1.08(0.70 –1.67)
 Mutation0.0140.49
  No1.001.00
  Yes1.59(1.09 –2.33)0.86(0.55 –1.33)
 Alteration0.0050.47
  No1.001.00
  Yes1.88(1.18 –3.00)1.21(0.72 –2.05)
 Conserved regions0.0070.8
  Nonconserved/WT1.001.00
  Conserved regions II, III, IV, V1.70(1.17 –2.47)1.06(0.69 –1.61)
 Im p53 (continuous)0.0560.64
  01.001.00
  101.04(1.00 –1.09)0.99(0.94 –1.04)
  201.09(1.00 –1.19)0.98(0.89 –1.07)
  501.23(0.99 –1.53)0.95(0.75 –1.20)
Other variables of interest
 Age (yr)d0.0030.005
  501.001.00
  601.26(1.08 –1.46)1.29(1.08 –1.55)
  701.58(1.17 –2.14)1.67(1.17 –2.40)
 Metastasis0.0620.6
  None1.001.00
  Any1.77(1.01 –3.10)1.18(0.64 –2.17)
 Lymph node status0.0010.54
  Negative1.001.00
  Positive4.20(1.82 –9.68)1.54(0.64 –3.71)
  Not resected3.13(1.42 –6.87)1.26(0.54 –2.94)
 Histology0.0210.9
  Serous1.001.00
  Other0.78(0.52 –1.16)1.03(0.65 –1.64)
 S-phase fraction0.0010.72
  0.0–4.9%1.001.00
  5.0–14.4%2.75(1.13 –6.68)1.47(0.43 –5.07)
  14.5% +4.88(1.95 –12.17)1.68(0.46 –6.19)
 DNA ploidy0.240.37
  Diploid1.001.00
  Tetraploid/Aneuploid1.38(0.80 –2.37)1.33(0.71 –2.51)
  • a On the basis of a previous analysis, FIGO, residual disease, and histological grade were selected for the baseline model.

  • b Ps based on the likelihood ratio of the univariate model with no other variables.

  • c Ps based on the likelihood ratio with the variables included in the baseline model: FIGO, residual disease, and histological grade.

  • d Age, in years, fit as a continuous variable.