Table 3

No. of patients with grade 3 or 4 toxicity by dose level

150 mg/kg/d225 mg/kg/d285 mg/kg/d345 mg/kg/d410 mg/kg/d515 mg/kg/d
Neurocortical11a
Hypokalemia1a
Hyperuricemia1a
Nausea1a
Neutropenia1b
Fatigue2c
  • a Toxicities occurred in the same patient.

  • b Lasted 2 days only.

  • c Felt to be related to disease progression rather than drug.