Table 4

Population pharmacokinetic estimatesa

MeanSD
PB (n = 20)
 volume of distribution, liter/kg0.1690.043
Vmax, μmol/h/kg14823
 kinc, 1/h0.00290.0015
 km, μmol/liter546159
PA (n = 19)
 volume of distribution, liter/kg0.7200.562
Vmax, μmol/h/kg7710
 kinc, 1/h0.00090.0006
 km, μmol/liter6228
Phenylacetylglutamine (n = 19)
 volume of distribution, liter/kg0.2810.130
 clearance rate, ml/min/kg1.831.15
  • a Kinc, rate constant of increase in Vmax after 24 h.