Proliferative response of CD4+ PBLs to TetA830 peptide
| SI values for all patients evaluated are shown in the table. Positive responses are those with a SI ≥4. The mean increases in reactivity were 3-, 108-, and 21-fold for the three groups. The results from patients with CTL responses to the gp100 peptide are shown in bold and were: patient 1120, who had a strong helper response; patient 1108, who had no helper response but was not vaccinated with the helper peptide; and patient 1105, who also was not vaccinated with the helper peptide. | ||||||
|---|---|---|---|---|---|---|
| Vaccinating peptide and adjuvant | SI | % of positive response to TetA830 | ||||
| Positive | Negative | |||||
| gp100280–288 | ||||||
| Montanide ISA-51 | 3.6; 3; 2; 1; 1 | 13 | ||||
| QS-21 | 14 | 1; 0 | ||||
| Mixture of gp100280 and TetA830 | ||||||
| Montanide ISA-51 | 403; 118 | 60 | ||||
| QS-21 | 16 | 1; 0 | ||||
| Chimera gp100280–TetA830 | ||||||
| Montanide ISA-51 | 48; 25 | 1 | 86 | |||
| QS-21 | 31; 26; 10; 8 | |||||