Table 1

Relative growth inhibition by three folate analogues against human mesothelioma cells linesa

TumorMTX IC50 (nm)EDX IC50 (nm)PDX IC50 (nm)
VAMT-1634 ± 8677 ± 1123 ± 4n = 3
JMN683 ± 6598 ± 1227 ± 4n = 3
  • a The cells were exposed to various concentrations of each analogue for 3 h then washed and resuspended in drug-free medium. Average of three determinations ± SE of the mean.