Table 3

Treatment of the JMN human mesothelioma with classical folate analogues with and without probenecida

RxWeight change (%)Average tumor diameter (mm ± SE)bChange in tumor vol (mm3)Average regression (%)Complete regressions (no./total)
AgentDose (mg/kg)
+0.38.3 ± 1+17710/12
MTX40−0.15.6 ± 2+2050/12
EDX40−0.24.8 ± 1+920/9
PDX60−0.13.0 ± 1−25522/12
PDX + PBCD60 + 125−0.12.5 ± 1−41865/9c
  • a See text for experimental details. Three to four experiments using three to four mice/group.

  • b Initial tumor volume = 4.5 ± 0.6 (48 mm3).

  • c Two of nine mice exhibited no regrowth of tumor 3 weeks after cessation of treatment.