Table 6

Treatment of the JMN human mesothelioma with PDX, platinum compounds, or a combination of both agentsa

RxWeight change (%)Average tumor diameter (mm ± SE)bChange in tumor vol (mm3)Average regression (%)Complete to regressions (no./total)
AgentDose (mg/kg)
+110.1 ± 1+27360/9
PDX60+13.0 ± 1−28541/9
CDDP2−45.1 ± 1+1230/9
CBDCA50−25.5 ± 1+1780/9
PDX + CDDP45 + 1.4−32.2 ± 1−46893/9
PDX + CBDCA45 + 35−61.9 ± 0.6−48924/9c
  • a Average of 3 experiments with 3 mice per group.

  • b Initial tumor volume = 4.8 ± 1 mm (52 mm3).

  • c No regrowth of tumor in one of nine mice 21 days after cessation of therapy.