Table 4

Clinical and pathological characteristics of familial and sporadic ovarian cancer

No. of cases (%)
BRCA1BRCA2No mutationPopulation controls 1Population controls 2
Total110107812991185
Age (yr)
 Mean ± SD52.1 ± 9.758.4 ± 13.649.7 ± 9.6a54.2 ± 13.5NDb
 Range28–7941–7425–6812–94
Histology
 Serous79 (79.8)c8 (88.9)d40 (54.8)e524 (44.3)575 (50.1)
 Endometrioid14 (14.1)08 (11.0)157 (13.3)134 (11.7)
 Mucinous0010 (13.7)273 (23.1)250 (21.8)
 Clear cell01 (11.1)11 (15.1)164 (13.9)143 (12.5)
 Others6 (6.1)04 (5.5)66 (5.6)46 (4.0)
 Unknown111511537
Stage
 I13 (13.8)f1 (11.1)g25 (45.5)h553 (43.1)390 (32.9)
 II7 (7.4)f0g9 (16.4)h167 (13.0)167 (14.1)
 III61 (64.9)f7 (77.8)g13 (23.6)h434 (33.9)480 (40.5)
 IV13 (13.8)f1 (11.1)g8 (14.5)h128 (10.0)148 (12.5)
 Unknown16123170
  • a P = 0.0076 (vs. controls 1).

  • b ND, not done.

  • c P = 1.0 × 10−10 (vs. controls 1), P = 4.1 × 10−9 (vs. controls 2).

  • d P = 0.0083 (vs. controls 1), P = 0.020 (vs. controls 2).

  • e P = 0.051 (vs. controls 1), P = 0.26 (vs. controls 2).

  • f P = 1.0 × 10−10 (vs. controls 1), P = 5.4 × 10−7 (vs. controls 2).

  • g P = 0.0077 (vs. controls 1), P = 0.030 (vs. controls 2).

  • h P = 0.25 (vs. controls 1), P = 0.022 (vs. controls 2).