Clinical and pathological characteristics of familial and sporadic ovarian cancer
| No. of cases (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| BRCA1 | BRCA2 | No mutation | Population controls 1 | Population controls 2 | |||||
| Total | 110 | 10 | 78 | 1299 | 1185 | ||||
| Age (yr) | |||||||||
| Mean ± SD | 52.1 ± 9.7 | 58.4 ± 13.6 | 49.7 ± 9.6a | 54.2 ± 13.5 | NDb | ||||
| Range | 28–79 | 41–74 | 25–68 | 12–94 | |||||
| Histology | |||||||||
| Serous | 79 (79.8)c | 8 (88.9)d | 40 (54.8)e | 524 (44.3) | 575 (50.1) | ||||
| Endometrioid | 14 (14.1) | 0 | 8 (11.0) | 157 (13.3) | 134 (11.7) | ||||
| Mucinous | 0 | 0 | 10 (13.7) | 273 (23.1) | 250 (21.8) | ||||
| Clear cell | 0 | 1 (11.1) | 11 (15.1) | 164 (13.9) | 143 (12.5) | ||||
| Others | 6 (6.1) | 0 | 4 (5.5) | 66 (5.6) | 46 (4.0) | ||||
| Unknown | 11 | 1 | 5 | 115 | 37 | ||||
| Stage | |||||||||
| I | 13 (13.8)f | 1 (11.1)g | 25 (45.5)h | 553 (43.1) | 390 (32.9) | ||||
| II | 7 (7.4)f | 0g | 9 (16.4)h | 167 (13.0) | 167 (14.1) | ||||
| III | 61 (64.9)f | 7 (77.8)g | 13 (23.6)h | 434 (33.9) | 480 (40.5) | ||||
| IV | 13 (13.8)f | 1 (11.1)g | 8 (14.5)h | 128 (10.0) | 148 (12.5) | ||||
| Unknown | 16 | 1 | 23 | 17 | 0 | ||||
a P = 0.0076 (vs. controls 1).
b ND, not done.
c P = 1.0 × 10−10 (vs. controls 1), P = 4.1 × 10−9 (vs. controls 2).
d P = 0.0083 (vs. controls 1), P = 0.020 (vs. controls 2).
e P = 0.051 (vs. controls 1), P = 0.26 (vs. controls 2).
f P = 1.0 × 10−10 (vs. controls 1), P = 5.4 × 10−7 (vs. controls 2).
g P = 0.0077 (vs. controls 1), P = 0.030 (vs. controls 2).
h P = 0.25 (vs. controls 1), P = 0.022 (vs. controls 2).