Table 1

Antitumor activity and toxicity of different schedules of topotecan administered i.p. in mice

Group of animalsSchedule of administrationaToxic death (%)Maximum weight loss (%)Cured mice (%)
112.5 mg/kg × 10416.67
22.5 mg/kg d × 5b33.32733.33
31.25 mg/kg (d × 5)2b16.671283.33
40.625 mg/kg (d × 5)4b03100
50.312 mg/kg (d × 5)8b00.1550
60.156 mg/kg (d × 5)16b0033.33
71.25 mg/kg (d × 5)q2wc01816.67
80.625 mg/kg [(d × 5)q2w]2c0550
  • a Topotecan treatment began 3 days after tumor implantation.

  • b Topotecan was administered i.p. 5 days/week, for 1, 2, 4, 8, or 16 consecutive weeks.

  • c Topotecan was administered i.p. 5 days/week every other week for a total of 4 or 8 weeks.