Table 3

Hematological toxicity: number of patients with hematological adverse events during treatment with Genasense and mitoxantrone

Dose levelGenasense (mg/kg/d)Mitoxantrone (mg/m2)No. of patients (courses)No. of patients with toxicity grade first course (all courses)
NeutrophilsPlateletsLymphocytes
1 or 23 or 41 or 23 or 41 or 23
10.643 (9)1 (2)01 (1)03 (4)1 (3)
21.243 (11)1 (3)01 (1)03 (10)1 (1)
32.043 (7)1 (1)0002 (5)0
43.143 (4)1 (1)01 (1)02 (2)0
53.184 (12)3 (6)1 (5)1 (1)01 (3)1 (1)
63.1124 (9)2 (2)4 (5)2 (4)01 (6)3 (4)
75.0126 (25)4 (15)2 (4)0 (4)03 (15)4 (7)