Table 5

Plasma pharmacokinetic parameters of mitoxantrone following Genasense

Dose levelNo. of patientsGenasenseMitoxantrone
Dose (mg/kg/day)Css (μg/ml)Dose (mg/m2)[AUC]0–α (ng·h/ml)Cp (ng/ml)t½α (h)t½β (h)Vc (liters)Vss (liters)Cl (liters/h)
643.02.82 ± 0.6612.0328.9 ± 52.6816.1 ± 202.20.21 ± 0.023.83 ± 3.132.8 ± 8.9173.3 ± 198.477.8 ± 11.0
765.04.29 ± 0.5212.0579.6 ± 172.71473.4 ± 886.50.19 ± 0.065.48 ± 2.719.3 ± 10.2144.9 ± 103.138.4 ± 11.51
P 0.00010.008nsansns0.02ns0.0003
  • a [AUC]0–α, area under the concentration-time curve; Cp, peak plasma concentration; Css, concentration in plasma at steady state; t½α, distribution half-life; t½β, elimination half-life; Vc, central compartment volume of distribution; Vss, volume of distribution at steady state; Cl, plasma clearance; ns, not significant.