Table 2

Results of multivariate analysis comparing TCD in bone marrow with other risk factors in patients with breast cancera

VariablePRR95% CI
 A. Distant disease-free survival
TCD (positive, negative)<0.0011.411.19 –1.67
Grade (I + II, III)<0.0011.381.16 –1.64
Nodal status (N0, N1–3, N4–9, N>9)<0.0011.251.15 –1.37
Tumor size (T1, T2, T3, T4)0.0701.220.98 –1.52
 B. Overall survival
Progesterone receptor (positive,b negative)0.0061.291.08 –1.55
TCD (positive, negative)0.0051.311.08 –1.58
Grade (I + II, III)0.0241.251.03 –1.51
Nodal status (N0, N1–3, N4–9, N>9)<0.0011.231.12 –1.35
Tumor size (T1, T2, T3, T4)0.0891.100.98 –1.23
  • a Cox regression stratified by adjuvant therapy; nodal status and tumor size were each included in the model as one variable with values 1, 2, 3, and 4 given to the groups as indicated. RR therefore refers to the comparison of one category to the next. Tumor staging according to UICC criteria.

  • b Positive ≥20 fmol/mg protein.