Table 1

HOSE cell colony formation in soft agar and tumorigenicity in SCID mice

Cell cultureColony sizeTumorigenicitya
≥50 μm≥10 but <50 μmNo. sites pos/no. sites
SKOV>60004/4
96.9.18
 Passage 3900NDb
 Passage 49000/8
 Passage 10640>200c0/8
1.24.96
 Passage 6000ND
 Passage 9016>200d0/8
96.9.18
 LC110>200cND
 LC225602/2
 LC31200/2
 LC41940ND
  • a Number of colonies/plate is the average of three experiments.

  • b ND, not done.

  • c Colony size ranged from 10–20 μm.

  • d Colony size ranged between 25–30 μm.