Table 1

Summary of the in vitro activities of SU11925 and ZD1839

Compound and cell lineEGFR IC50 (cell)HER-2 IC50 (cell)
SU11925
 A43130 nmNAa
 NIH3T3/HER-2NA75 nm
 SK-OV-3TP5NA38 nm
ZD1839
 A43130 nmNA
 NIH3T3/HER-2NAND
 SK-OV-3TP5NA>2000 nm
  • a NA, not applicable; cell lines did not express receptor in sufficient quantity for analysis. ND, not determined.