Table 1

Kinetic parameters for metabolism of BG, 8-oxoBG and DTIC

SubstratesEnzymeKMm)Vmax (pmol/min/pmol)Vmax/KM
BGCYP1A16.4 ± 0.40.5 ± 0.090.08
BGaCYP1A21.3 ± 0.081.7 ± 0.041.31
BGaCYP3A452.2 ± 7.140.3 ± 0.010.0057
8-oxoBGCYP1A118.3 ± 1.33.1 ± 0.070.17
8-oxoBGbCYP1A235.9 ± 12.80.6 ± 0.20.016
DTICCYP1A1306 ± 24477 ± 1451.56
DTICCYP1A2327 ± 16165 ± 70.51
  • a Data cited from Roy et al. (13) .

  • b Data cited from Long et al. (14) .