Table 2

Response of human glial tumor xenografts in athymic mice to a single i.p. treatment with BCNU: Effect of dose

TumorBCNUa mg/m2No. of animalsNo. of deathsWeight loss Mean %No. of regressionsMedian to 5× treatment volumeT-Cb Days
D-54356020102
SWB61356010120
SWB3935600010−1
SWB40356010110
SWB7735600010−1
D-5465
SWB616510036219c
SWB3965100362211c
SWB406513053164c
SWB776510033121
D-54701211062618c
SWB61706083208c
SWB397060932110c
SWB40706092198c
SWB77706090143
D-54751242342719c
  • a BCNU stock 10 mg/ml in 100% ethanol was diluted to appropriate concentrations with 5% ethanol. BCNU was injected i.p. (injection volume, 0.15–0.2 ml/animal).

  • b Tumor growth delay as compared with untreated controls. Animals were killed when tumor exceeded 1200 mm3.

  • c Statistically significant (P < 0.05) as compared with untreated controls or to those treated with 35 mg/m2 BCNU.