Table 5

Response of human glial tumor xenografts in athymic mice to a single i.p. treatment with TMZ

TumorTMZa mg/m2No. of animalsNo. of deathsWeight loss Mean %No. of regressionsMedian to 5× treatment volumeT-Cb Days
SWB773001009103423
SWB772001006103019
SWB4030010010106653
SWB402001005105946
SWB6160012610106154
SWB613001001096356
SWB612001006106154
  • a TMZ was dissolved in DMSO and injected i.p. (injection volume, 0.15–0.2 ml/animal).

  • b T-C tumor growth delay as compared with untreated controls. All values were statistically significant as compared with untreated controls.