Table 6

Response of human glial tumor xenografts in athymic mice to a single treatment of BG or dBG, followed by a single i.p. treatment with TMZ

TumorTMZa mg/m2AGT inhibitor mg/m2No. of animalsNo. of deathsWeight loss Mean %No. of regressionsMedian to 5× treatment volumeT-Cb Days
SWB77180180 (BG)1209124331
SWB77180250 (dBG)12010126149
SWB40180180 (BG)12010126856
SWB40180250 (dBG)12011127563
  • a TMZ was dissolved in DMSO. dBG and BG were dissolved in 40% PEG in PBS. TMZ was injected i.p. (injection volume, 0.15–0.2 ml/animal) 2 h after treatment with i.p. dBG (injection volume, 0.2–0.3 ml/animal).

  • b T-C tumor growth delay as compared with untreated controls. All values were statistically significant as compared with untreated controls.