Table 4

Cox proportional hazards regression analysis of resistance markers

MarkerHazards ratioSEzP
P-gpa1.520.2981.410.160
GST-πa1.820.3571.680.093
TS1.750.2841.970.048
Cisplatin resistanceb1.640.2102.370.018
TS1.760.2841.990.047
  • a If the two significant platinum markers were added separately, there was marginal significance for each. However, the total model remained significant at P = 0.017.

  • b A variable created as the number of cisplatin markers expressed (range, 0 to 2 for GST-π and P-gp) allowed a multivariate model with significant independent predictive value (total model, P = 0.006).