Table 1

NEP inhibits xenograft tumor formation in the prostates of athymic mice

Athymic mice were injected with 2 × 106 cells as described in “Materials and Methods.” Animal were fed with Dox-Diet (Dox, +) or regular feed (Dox, −) and killed at 30 days.
Cell lineDoxTumor formationTumor sizea (mm3)Mouse weightb (g)
WT-5+4/5 (80%)0.43 (0.11)6.1 (2.4)
WT-51/5 (20%)0.07 (0.07)5.7 (2.8)
TN-12+4/4 (100.0%)0.91 (0.35)5.5 (2.3)
TN-124/4 (100.0%)1.04 (0.42)6.2 (1.9)
  • a Tumor size measured in mm3 and calculated as length × width × depth/2. Tumor measurements were performed by two researchers independently; in parentheses, SE.

  • b Average change in animal weight over 30 days of experiment; in parentheses, SE.