Table 1

Tubulin polymerization potency of three epothilones relative to paclitaxel

AnalogPolymerization potency EC0.01 (μM)Ratio of polymerization Potency of analog: Paclitaxel
BMS-2475503.5 ± 0.40.4
Epothilone A2.0 ± 0.20.4
Epothilone B1.8 ± 0.20.3
Paclitaxel8.5 ± 1.4, 5.0 ± 1.0, 6.0 ± 0.71.0