Table 2

Tumor model characteristics

TumorHistologySourcePaclitaxel sensitivityResistance mechanism(s)
Human
 Pat-26PancreaticBiopsyInsensitiveUnknown
 Pat-7OvarianBiopsyResistant1MDR,2MRP3
 A2780TaxOvarianCell lineResistantTubulin mutation
 HCT116/VM46ColonCell lineResistantMDR
 Pat-21BreastBiopsyResistant1Unknown
 A2780OvarianCell lineSensitive
 HCT116ColonCell lineSensitive
 LS174TColonCell lineSensitive
Murine
 M5076FibrosarcomaCell lineInsensitiveUnknown, non-MDR
  • 1 Clinical resistance to Taxol®.

  • 2 MDR, multidrug resistance attributable to P-glycoprotein overexpression.

  • 3 MRP, multidrug resistance-related protein.