Table 2

Effect of ZD1839 on growth of human cancer cell lines in soft agar

IC50s were calculated by performing dose-response experiments. Cancer cells were treated with different concentrations of ZD1839 (range, 0.05–2.5 μm) each day, for a total of 5 days. Colonies were counted after 10–14 days.
Cell lineZD1839 IC50m)
ZR-75-10.2
MCF-7 ADR0.15
OVCAR-30.25
GEO0.4
SW4800.3
CaCo20.6
KATO III0.2
N870.9