Effect of ZD1839 on growth of human cancer cell lines in soft agar
| IC50s were calculated by performing dose-response experiments. Cancer cells were treated with different concentrations of ZD1839 (range, 0.05–2.5 μm) each day, for a total of 5 days. Colonies were counted after 10–14 days. | ||
|---|---|---|
| Cell line | ZD1839 IC50 (μm) | |
| ZR-75-1 | 0.2 | |
| MCF-7 ADR | 0.15 | |
| OVCAR-3 | 0.25 | |
| GEO | 0.4 | |
| SW480 | 0.3 | |
| CaCo2 | 0.6 | |
| KATO III | 0.2 | |
| N87 | 0.9 | |