Table 3

Patients reporting severe NCI grade 3–4 treatment related adverse events by age (incidence ≥5%)

The incidence of NCI grade 3 or 4 grade 3–4 treatment-related events appeared similar in the subgroup of patients ≥60 years of age, compared with the overall incidence of adverse events.
Adverse eventAll Patients (n = 142)Age ≥60 (n = 80)
Body as a whole
 Neutropenic fever10 (7)4 (5)
 Sepsis23 (16)12 (16)
Cardiovascular system
 Hypertension13 (9)9 (11)
 Hypotension11 (8)6 (8)
Respiratory system
 Dyspnea13 (9)10 (13)
 Pneumonia10 (7)5 (6)
NCI Grade 3–4 laboratory abnormalities
 Hematological
  Hemoglobin66/141 (47)36/80 (45)
  Absolute neutrophils137/140 (98)78/79 (99)
  Platelets139/141 (99)79/80 (99)
 Nonhematological
  Creatinine2/141 (1)0/80 (0)
  Total bilirubin33/141 (23)18/80 (23)
  AST24/141 (17)12/80 (15)