Table 3

Dexrazoxane plasma pharmacokinetics

Dose (mg/m2/day)CLss (l/h/m2)t1/2 (h)Css (μg/l)AUC (mg/l × h)
1255.82.1895.580.4
1255.92.3885.874.4
1258.02.0650.460.8
1256.71.6777.470.7
1258.31.4634.061.9
12510.41.2496.447.8
166.256.22.31131.2102.9
166.257.82.3877.379.7
166.256.02.21130.3112.2
166.256.11.81155.7114.3
166.255.83.21175.3112.9
166.255.14.31353.7123.4
166.2510.01.0699.963.1
2219.32.9988.583.3
2217.31.01264.8119.7
2218.62.21073.2100.1
2216.51.61407.8135.2
2217.11.41290.3114.8
2215.81.41569.1151.1
2506.42.41639.2138.3
25010.00.91040.595.5
Mean7.22.0
Median6.72.0
SD1.60.8