Table 2

Correlation between apoptotic counts per 1000 and other markers

MarkersAll patientsLN−LN+
nr95% CIaPnr95% CIPnr95% CIP
Age791−0.16(−0.23–−0.10)<0.0001331−0.15(−0.26–−0.04)0.0057335−0.11(−0.21–−0.00)0.0472
Elston grade7550.40(0.33–0.45)<0.00013140.45(−0.35–0.53)<0.00013200.37(0.27 –0.46)<0.0001
Tumor size7900.08(0.01–0.15)0.03043310.06(−0.04–0.17)NS3340.09(−0.01–0.20)NS
LN mets666−0.001(−0.08–0.08)NS335−0.026(−0.13–0.08)NS
ER781−0.29(−0.35–−0.22)<0.0001328−0.34(−0.43–−0.24)<0.0001333−0.25(−0.35 –−0.15)<0.0001
MIB-17910.36(0.30–0.42)<0.00013310.36(0.26–0.45)<0.00013350.32(0.22 –0.42)<0.0001
Mits/10007910.46(0.41–0.52)<0.00013310.54(0.46–0.61)<0.00013350.39(0.30 –0.48)<0.0001
Mits/10 HPFs7910.32(0.25–0.38)<0.00013310.33(0.23–0.42)<0.00013350.28(0.18 –0.38)<0.0001
p53 7880.22(0.15–0.29)<0.00013300.30(0.20–0.39)<0.00013340.14(0.04 –0.25)0.0095
erbB-2 7870.20(0.13–0.26)<0.00013300.15(0.04–0.25)0.00713350.25(0.15 –0.35)<0.0001
Apoptosis by TUNEL2321.15(0.02–0.27)0.02381040.08(−0.11–0.27)NS910.23(0.03–0.42)0.0260
  • a CI, confidence interval; NS, not significant; mets, metastases; Mits, mitoses.