Table 3

Factors associated with outcomes of breast cancer patients using Cox proportional hazard model (univariate analysis for all patients)

FactorsnDFSDSS
r95% CIPr95% CIP
Age
 <5018411
 ≥505890.862(0.69–1.08)0.190.903(0.70 –1.16)0.42
Tumor grade
 17211
 23461.524(1.02–2.28)<0.00011.439(0.91 –2.29)<0.0001
 33222.296(1.54 –3.43)2.474(1.57–3.91)<0.0001
Tumor size
 ≤2 cm34611
 >2 cm4271.509(1.23–1.85)<0.00011.367(1.09 –1.71)0.0067
Lymph node
 Negative32211
 Positive3292.724(2.15–3.45)<0.00013.05(2.32 –4.01)<0.0001
Lymph node’s
 032211
 1–31801.964(1.49–2.59)<0.00012.057(1.49 –2.84)<0.0001
 4+1494.094(3.13 –5.36)4.848(3.58 –6.57)
ER
 Negative33011
 Positive4330.707(0.58–0.86)0.00060.652(0.52 –0.81)0.0002
erbB-2
 <40%61611
 ≥40%1531.37(1.08–1.74)0.00911.474(1.14 –1.91)0.0034
p53
 Negative54611
 Positive2241.169(0.94–1.45)0.150.275(1.01 –1.61)0.0428
MIB-1
 <17.8%38411
 ≥17.8%3891.697(1.39–2.07)<0.00011.765(1.41 –2.21)<0.0001
Mitosisa
 <2.3338011
 ≥2.333931.54(1.26–1.88)<0.00011.782(1.42 –2.23)<0.0001
Mitoses/10 HPFs
 <636411
 ≥64091.529(1.25–1.87)<0.00011.758(1.40 –2.21)<0.0001
Apoptosisb
 <3.6837911
 ≥3.683941.397(1.15–1.70)0.00091.474(1.18 –1.84)0.0006
 <5.04641
 ≥5.03091.487(1.22–1.81)<0.00011.583(1.27 –1.98)<0.0001
  • a Mitotic count per 1000.

  • b Apoptotic count per 1000.