Table 4

Multivariate survival analyses

Variables in modelNo. of patientsNo. of eventsχ2Δχ2P
I. All patients
 A. Base = LN+ + Size+ER+erbB-2645312143.22
 DFS
  Base + Apoptosisa645312145.862.640.10
  Base + Mitosisb645312143.480.260.62
  Base + Mits/10 HPFs645312143.850.630.43
  Base + MIB-1645312146.223.530.06
 B. Base = LN+ + Size+Grade+ER+erbB-2618235134.54
 DSS
  Base + Apoptosis618235135.210.070.41c
  Base + Mitosis618235135.611.070.30
  Base + Mits/10 HPFs618235134.560.020.88d
  Base + MIB-1618235137.172.630.10d
II. LN− patients
 A. Base = Size+Grade30710119.92
 DFS
  Base + Apoptosis30710121.371.450.23
  Base + Mitosis30710127.637.710.0055c
  Base + Mits/10 HPFs30710121.461.540.21
  Base + MIB-130710122.102.170.14c
 B. Base = Grade308728.57
 DSS
  Base + Apoptosis308728.670.100.76
  Base + Mitosis308729.571.000.32c
  Base + Mits/10 HPFs308729.611.040.20c
  Base + MIB-13087210.211.640.020
III. LN+ patients
 A. Base = LN+ + Size+ER+erbB-232720863.82
 DFS
  Base + Apoptosis32720863.960.130.72
  Base + Mitosis32720867.944.110.043e
  Base + Mits/10 HPFs32720865.721.900.17
  Base + MIB-132720864.380.550.46
 B. Base = LN+ + Age+ER+erbB-232517179.34
 DSS
  Base + Apoptosis32517181.241.910.17
  Base + Mitosis32517181.051.720.19
  Base + Mits/10 HPFs32517179.440.100.75
  Base + MIB-132517183.013.680.06
  • a Apoptotic count per 1000.

  • b Mitotic count per 1000.

  • c Grade was not significant.

  • d Grade and ER were not significant.

  • e Size was no longer significant.