Table 1

BM findings according to the age, disease stage, and cytogenetic aberrations of the primary tumor of 41 NB patients identified by the automatic microscopic procedure

Tumor cell positivity was stated when the tumor typical cytogenetic aberrations were found in at least two GD2 immunolabeled cells by a targeted sequential FISH analysis after automatic repositioning (GD2+/FISH+).
PatientAgeaDisease stageGenetic aberration in the primary tumorNo. of punctionGD2+ samplesGD2+/FISH+ samples
19 m1del1p400
24 y1Trisomy 1 and 2200
313 m1Pentasomy 1420
43 m2BTrisomy 1 and 2400
511 m2Bdel1p200
611 m2Bimb1p, 17q gain430
74 y317q gain100
810 m3Trisomy 1 and 2400
94 y3n.t.b400
1011 m3Tri- and hexasomy 1 and 2200
113 y3MYCN ampl430
1212 m317q gain430
133 y3del1p, MYCN ampl440
142 y4Tri- and tetrasomy 1 and 2444
153 y417q gain222
1612 y417q gain111
172 y417q gain111
182 y4imb1p444
196 y4del1p444
2012 y4del1p444
218 m4del1p222
224 y4imb1p111
2315 m4del1p, MYCN ampl333
2414 m4del1p, MYCN ampl400
253 y4del1p, gain MYCN222
262 y4del1p, MYCN ampl111
273 y4del1p, gain MYCN111
284 y4del1p, MYCN ampl, 17q gain222
292 y4del1p, MYCN ampl, 17q gain111
304 y4imb1p, MYCN ampl, 17q gain433
315 y4del1p, MYCN ampl, 17q gain444
3218 m4imb1p, MYCN ampl, 17q gain433
335 y4del1p, MYCN ampl, 17q gain111
342 y4del1p, MYCN ampl, 17q gain111
352 m4sTrisomy 1433
361 m4sTrisomy 1433
3710 m4sTrisomy 1 and 2444
384 m4sTrisomy 1 and 2222
395 m4sTetrasomy 1311
4013 m4sTri- and tetrasomy 17444
  • a m, month; y, year.

  • b n.t., not tested.