Table 2

LOH at chromosome locus 5p21 in breast and lung cancer cell lines

MarkeraMarker typeNo. with LOH / No. of informative cases (% LOH)Pb
Breast (n = 14)SCLC (n = 13)NSCLC (n = 18)
D5S656Microsatellite4/6 (67)4/7 (57)1/10 (10)0.1
D5S658Microsatellite8/11 (73)6/8 (75)3/12 (25)0.07
D5S489Microsatellite4/9 (44)5/6 (83)1/10 (10) 0.01
D5S346Microsatellite10/12 (83)8/10 (80)3/12 (25) 0.03
APC exon 11RsaI3/5 (60)6/6 (100)2/5 (40)0.07
APC exon 15AspHI5/7 (71)6/6 (100)2/5 (40)0.07
D5S1468Microsatellite5/8 (62)3/6 (50)2/6 (33)1.0
D5S404Microsatellite7/10 (70)7/10 (70)4/12 (33)0.19
D5S494Microsatellite7/9 (78)7/12 (80)2/12 (17)0.09
D3S639Microsatellite7/10 (70)6/8 (75)2/3 (67)1.0
D5S429Microsatellite8/15 (53)7/7 (100)2/12 (17) 0.01
D5S471Microsatellite6/8 (75)7/9 (78)5/12 (42)0.18
Any marker11/16 (69)11/13 (85)15/18 (83)
  • a Although the precise order of the markers is controversial, the markers are arranged, as best we could determine, in order from centromeric (D5S656) to telomeric (D5S471).

  • b Comparison of LOH frequencies between SCLC and NSCLC lines was performed using Fisher’s exact test, two-sided. Statistically significant values are shown in boldface.