Table 3

Schedule optimization of oral BMS-275183 in mice bearing s.c. M109 lung carcinoma

ScheduleaCumulative dose (mg/kg)Lethality incidenceLog cell kill
2qd × 7
6845/8
4561/80.1
2.5350/80.1
qd × 7
14986/8
10701/80.4
6420/80.1
q2d × 4
451808/8
301201/80.6
20801/80.5
13520/80.7
q3d × 3
601804/8
451351/80.7
30900/80.7
20600/80.6
q6d × 2
1202403/8
901801/80.9b
601200/80.6
  • a All treatments were p.o. beginning on day 4 after tumor implant (in mg/kg/administration).

  • b Significantly different (P < 0.01) from best result obtained using 2qd × 7 schedule.