List of differentially expressed genes in the ESCC cell lines HKESC-1 and HKESC-2 when compared with one corresponding, morphologically normal, esophageal epithelium tissue specimen (N) from the HKESC-2-related patient using cDNA expression array
| Location | Name of gene | Intensity Ratio | ||
|---|---|---|---|---|
| HKESC-1/N | HKESC-2/N | |||
| Genes up-regulated in both ESCC cell lines | ||||
| Oncogene/Tumor suppressor genes | ||||
| A1a | c-myc | 2.5 | 3.0 | |
| A2b | IGFBP-2 | 6.9 | 6.0 | |
| A3b | Snon | 7.2 | 6.0 | |
| A3i | rhoA (MDR protein) | 2.8 | 3.9 | |
| A3k | DCC | 5.1 | 3 | |
| A4b | APC | 2.6 | 3.9 | |
| A4c | BRCA2 | 30029/0 | 42730/0 | |
| A4f | Fra-1 | 10.8 | 7.8 | |
| A4g | Ezrin | 21936/0 | 36475/0 | |
| A4h | JUN-D | 35.4 | 60.6 | |
| A4j | PEP1 | 3.6 | 4.8 | |
| A4k | EB1 | 2.6 | 3.0 | |
| A4l | C-CBL | 2.7 | 2.2 | |
| A4m | SmadI | 3.2 | 3.0 | |
| A4n | Neogenin | 2.4 | 3.2 | |
| Cell cycle-related genes | ||||
| A5e | Id-1 | 3.4 | 3.7 | |
| A5g | P58/GTA1 | 4.0 | 2.2 | |
| A6g | Cyclin D1 | 2.1 | 2.3 | |
| A6l | Cyclin B1 | 2.4 | 3.2 | |
| A6m | Cyclin E | 3.5 | 3.3 | |
| A7b | Cyclin G2 | 2.4 | 3.1 | |
| A7d | p35 | 6.9 | 7.2 | |
| A7l | C-1 | 2.6 | 2.6 | |
| A7m | CDC25B | 2.0 | 2.5 | |
| Apoptosis-associated genes | ||||
| C1i | Adenosine A1 receptor | 22.2 | 5.9 | |
| C4l | Apopain | 8.7 | 13.7 | |
| Genes for DNA synthesis/repair/recombination proteins | ||||
| C6d | XRCC1 | 3.2 | 2.9 | |
| C6l | DNA Topoisomerase II | 14759/0 | 22201/0 | |
| C7n | Dnase X | 5.1 | 4.4 | |
| Genes for DNA binding/transcription factors | ||||
| D1c | CCAT-binding protein | 9.9 | 8.8 | |
| D1d | Id-3 | 6.5 | 6.6 | |
| D1e | BTEB2 | 7.4 | 9.0 | |
| D1g | Id-2 | 9.8 | 7.6 | |
| D1l | TAX | 3.0 | 4.4 | |
| D1n | CNBP | 4.3 | 2.1 | |
| D2a | CCAAT displacement protein | 4.2 | 4.5 | |
| D2c | APRF | 33987/0 | 29011/0 | |
| D2d | hSNF2b | 42.2 | 40.7 | |
| D2f | TAXREB67 | 39440/0 | 49383/0 | |
| D2i | TCF5 | 37478/0 | 23080/0 | |
| D3a | hSNF2a | 7.1 | 4.2 | |
| D3b | DB1 | 316.5 | 225.0 | |
| D3c | D-binding protein | 37796/0 | 21621/0 | |
| D3g | PAX-8 | 13.6 | 7.2 | |
| D3j | P15 subunit | 38725/0 | 40864/0 | |
| D3k | Guanine nucleotide-binding protein G-S | 33.0 | 49.2 | |
| D4c | AP-2 | 7.1 | 4.9 | |
| D4j | NF-E1 | 34506/0 | 15924/0 | |
| D5k | PAX3 | 24.8 | 10.6 | |
| D7k | TAFII31 | 7.0 | 4.8 | |
| Genes for signal proteins | ||||
| F5a | NGF-2 | 16.7 | 4.6 | |
| F5b | MIP2α | 39223/0 | 19827/0 | |
| F5f | IL-8 | 39239/0 | 11638/0 | |
| Genes down-regulated in both ESCC cell lines | ||||
| Gene for iron channel/transport protein | ||||
| B1b | MAL protein | 1/3.3 | 0/11989 | |
| Genes for signal transduction | ||||
| B4g | Guanine nucleotide regulatory protein NET1 | 0/28564 | 1/23.7 | |
| B5j | Protein kinase c-β II | 0/29588 | 0/29588 | |
| B6b | cAMP-dependent protein kinase α-subunit | 0/41060 | 1/304 | |
| B6n | EPLG3 | 0/22304 | 1/2.5 | |
| Genes for cell signaling proteins | ||||
| F1a | Somatomedin A | 0/19560 | 0/19560 | |
| F1k | FMLP-related receptor I | 0/29220 | 0/29220 | |
| F2j | RANTES protein T-cell specific | 0/36868 | 1/3.2 | |