Table 3

Summary of IH staining results in clinical ESCC tumors and normal esophageal epithelium tissues

Diagnosis	Fra-1							P	Neogenin							P	Id-1							P	P
Diagnosis		−^a	+	++	+++		−	P	+	++	+++		−	+	++	P	+++		−	+	++	+++		P	P
Normal (n = 16)	1	15	0	0	<0.0001	6	10	0	0	<0.0001	3	12	1	0	<0.0001	9	7	0	0	<0.0001
Carcinoma (n = 61)	4	4	22	31	<0.0001		3	1	7	<0.0001	50		3	1	<0.0001	8	49		10	<0.0001	3	19	29
Well (n = 20)	0	0	9	11		1	0	2	17		0	1	3	16		2	2	7	9
Moderate (n = 29)	1	0	11	17	<0.0001	0	0	1	28	0.0047	0	0	3	26	0.0156	6	1	10	12	0.5720
Poor (n = 12)	3	4	2	3		2	1	4	5		3	0	2	7		2	0	2	8

^a Expression: −, no expression; +, <10% cells positive; ++, ≥10% and <50% cells positive; +++, ≥50% cells positive. ++ to +++ was considered as overexpression.