Table 2

Neutrophil production

ControlSD/01G-CSF
Normal miceNeutropenic miceNormal miceaNeutropenic mice
Maximum neutrophil countb × 10−9/l1.8 ± 0.215.5 ± 2.524.0 ± 2.825.7 ± 3.218.0 ± 2.5
Time of peak appearance in peripheral blood (days)3.41111
Peripheral half-life, t1/2 (h)8c13.7d9.29.7ND
Amplification factor18.814.914.510.1
Extra maturation divisions033.93.83.3
  • a Data from Lord et al. (4) .

  • b Mean values for three mice in each group ± SE.

  • c Assumed because the descending arm of the control curve was not sufficiently defined.

  • d As calculated (see text).