Table 1

Effect of CEP-751 treatment on prostate cancer volume, proliferation, and death rate

Tumor typehostTreatment (time)Cancer volumeaPercentage of Cancer Cells
Proliferation dayDying day
AT-2RatsVehicle (10 days)15.2 ± 1.149.3 ± 3.224.5 ± 1.8
CEP-751b (10 days)6.1 ± 0.5c57.6 ± 1.437.2 ± 4.1c
LNCaPNude miceVehicle (21 days)4.2 ± 0.323.4 ± 5.114.0 ± 2.1
CEP-751b (21 days)1.7 ± 0.2c25.2 ± 6.321.8 ± 2.5c
  • a Cancer volume expressed as fold increase from initiation of treatment.

  • b CEP-751 given s.c. at 10 mg/kg/dose. For AT-2, rats were given one dose/day; for LNCaP and TSU-pr1, nude mice were given two doses/day.

  • c P < 0.01 versus vehicle control.